Enomoto, R., Koshiba, C., Suzuki, C., and Lee, E. Wogonin potentiates the antitumor action of etoposide and ameliorates its adverse effects. Pharmacology 2006;77(2):71-77. Indian J Med Res 2008;127(6):610-615. The purpose of this study was to investigate whether SB exhibited anticancer activity in EGFR TKI-resistant lung cancer cells and to explore the underlying mechanism. View abstract. B., Ro, J. Y., and Woo, S. S. Antiallergic herbal composition from Scutellaria baicalensis and Phyllostachys edulis. View abstract. Drug Metab Dispos 2005;33:537-46. Therefore, one should not take the herb on their own Rather; they should ask a doctor and go with a suitable preference for treating cancer. Flavocoxid, a dual inhibitor of cyclooxygenase and 5-lipoxygenase, blunts pro-inflammatory phenotype activation in endotoxin-stimulated macrophages. Vaccine 1-8-2010;28(3):737-743. B., Blach-Olszewska, Z., and Aliev, G. Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration? Nontoxic; LD 50 is tested, none. Vopr.Onkol. Scutellaria is multi-functional: antioxidant, anti-inflammatory, and antithrombic agent, as well as neuroprotectant Diabetes medications are also used to lower blood sugar. Mol Pharmacol 2001;60(3):507-513. Available at: https://www.cancer.gov/about-cancer/treatment/cam/hp/pc-spes-pdq. View abstract. This herb is often used alone, whereas many times, it is used with other herbs in combination. Use of this Web site does not create an expressed or implied physician-patient relationship. View abstract. Baikal skullcap (Scutellaria baicalensis) is a plant native to China and Korea. Baikal skullcap might also lower blood sugar. Taking Baikal skullcap along with medications that also slow blood clotting might increase the risk of bruising and bleeding. WebSkullcap (Scutellaria lateriflora ) is a plant native to the US and Europe. Guang.Pu.Xue.Yu Guang.Pu.Fen.Xi. Qherb specializes in plant extract and the development of the most effective and specialized botanical ingredients for the pharmaceutical, beverage, health food, and Cosmetic industries. View abstract. Hu, Z., Yang, X., Ho, P. C., Chan, S. Y., Heng, P. W., Chan, E., Duan, W., Koh, H. L., and Zhou, S. Herb-drug interactions: a literature review. Hu, J. Anticonvulsant effect of wogonin isolated from. Baicalein: an in vitro antigenotoxic compound from Scutellaria baicalensis. Nat Prod Res 2008;22(16):1410-1412. You may ask and answer a query. Effect of Scutellaria baicalensis extract on the immunologic status of patients with lung cancer receiving antineoplastic chemotherapy. From diagnosis to treatment, our experts provide the care and support you need, when you need it. View abstract. View abstract. View abstract. Monitor your blood sugar closely. This might increase the side effects of some medications. Baikal skullcap might lower blood sugar levels. Luna-Bastante L, Gatica-Ortega ME, Pastor-Nieto MA, et al. View abstract. Br J Pharmacol 2009;157:1410-18. Cancer Sci 2011;102(4):870-876. J Ethnopharmacol. Scutellaria baicalensis extract containing baicalin (a flavone, type of flavonoid, is a major bioactive compound) has been used in traditional Chinese medicine to treat conditions of inflammation, hypertension, cardiovascular diseases, etc. Suppose you are taking any particular hormone synthesis medicine. It is also effective against some bacteria. Clin Pharmacol Ther 2007;83:471-6. The effect of he jie decoction on the TCRV beta 7 of chronic hepatitis B patients. In animal models, attenuation of asthma was attributed to reduced airway injury and restored mitochondrial function(19). Ye F, Wang H, Jiang S, et al. [Effect of Radix scutellariae on the growth and form of Porphyromanus endodontics in vitro]. View abstract. View abstract. Neo-clerodane diterpenoids also have demonstrated anticancer(24) and antiviral(25) activities. Daugel'-Dauge, N. O., Durnev, A. D., Kulakova, A. V., Seredenin, S. B., and Velichkovskii, B. T. [Corpuscular mutagenesis and its prevention]. This Chinese herb may slow down blood clotting, increasing the risk of bleeding and bruising in people who already have some bleeding disorders. Enomoto, R., Koshiba, C., Suzuki, C., and Lee, E. Wogonin potentiates the antitumor action of etoposide and ameliorates its adverse effects. The total content of these 6 main flavonoids account ed for 68.5% of the extract . View abstract. Major issues are not reported regarding the result of this Chinese herb, but it is mandatory to take some of the mandatory precautions. Baikal skullcap can also affect most peoples blood sugar levels, but people with diabetes can get negative results with the herb. J Med Chem 10-21-2004;47(22):5555-5566. The active ingredient in Baikal skullcap, baicalin, is used in combination with shung hua (ephedra) to treat upper respiratory tract infections. View abstract. A., Ruscetti, F. W., and Wang, J. M. Flavonoid baicalin inhibits HIV-1 infection at the level of viral entry. View abstract. 9-7-2009;125(2):286-290. Bioorg.Med Chem 8-1-2008;16(15):7516-7524. Reichenbach S, Juni P. Medical food and food supplements: not always as safe as generally assumed. J Ethnopharmacol. Eksp Klin Farmakol 1997;60:28-30. Neurosci Lett. Morgan SL, Baggott JE, Morel, L, Desmond R, and Kendrach AC. S. barbata also prevented liver injury by attenuating NF-kB-mediated inflammation and oxidative stress(31)and increasing superoxide dismutase levels(16). Guangxi Zhiwu 2008;28(3):373-378. Your lithium dose might need to be changed. Chen, Y., Lu, N., Ling, Y., Gao, Y., Wang, L., Sun, Y., Qi, Q., Feng, F., Liu, W., Liu, W., You, Q., and Guo, Q. Wogonoside inhibits lipopolysaccharide-induced angiogenesis in vitro and in vivo via toll-like receptor 4 signal transduction. Tseng-Crank J, Sung S, Jia Q, and et al. View abstract. View abstract. View abstract. WebBaicalin is a great herbal supplement for health benefits. Baicalin from the extract of Scutellaria baicalensis affects the innate immunity and apoptosis in leukocytes of children with acute lymphocytic leukemia. 2003;34(3):504-506. In liver tumors, S. barbata flavonoids suppressed angiogenesis via VEGF regulation, MMP2/9 inhibition, and increased TIMP1/2 expression(17)(29). Z., and Liu, Y. W. Wogonin, a bioactive flavonoid in herbal tea, inhibits inflammatory cyclooxygenase-2 gene expression in human lung epithelial cancer cells. View abstract. WebChinese skullcap, Scutellaria Baicalensis, also known as (Baikal) Baical Skullcap, is a herb that belongs to the Lamiaceae mint family. View abstract. View abstract. Blaszczyk T, Krzyzanowska J, Lamer-Zarawska E. Screening for antimycotic properties of 56 traditional Chinese drugs. 1997;57(1):63-67. WebAllergy Anaphylactic Anorexia Bleeding Ext Bloody Stools Bronchiolitis Cancer Chest Pain Diarrhea Dipsia Dysuria Eczema Eyes Bloodshot Fever Food Allergy Study on the effects of extracts from Scutellaria baicalensis combined with cisplatin on apoptosis of human ovarian carcinoma cell line SKOV-3. BMC.Complement Altern Med 2006;6:27. You are encouraged to report negative side effects of prescription drugs to the FDA. View abstract. View abstract. View abstract. A., Lee, K., Hwangbo, H., Park, E., Kim, M., and Ma, W. Detection of the potential adulterant Teucrium chamaedrys in Scutellaria baicalensis raw material and extract by high-performance thin-layer chromatography. View abstract. Intern Med 2001;40:764-8. Zhou J, Qu F, Yu Y, et al. Surgery: Baikal skullcap might slow blood clotting. Orzechowska B, Chaber R, Wisniewska A, et al. Ju, W. Z., Liu, F., Wu, T., Xia, X. Y., Tan, H. S., Wang, X., and Xiong, N. N. [Simultaneous determination of baicalin and chlorogenic acid in human plasma by UPLC-MS/MS]. Pharmacol Biochem Behav 2009;92(4):642-648. View abstract. [Pharmacological effects of flavonoids from Scutellaria baicalensis]. View abstract. View abstract. Watanabe S, Kitade Y, Maski T, Nishioba WebSide Effects Precautions Interactions Dosing Reviews (4) Overview Baikal skullcap (Scutellaria baicalensis) is a plant native to China and Korea. 11-1-2009;284(2):198-207. Razina, T. G., Zueva, E. P., Litvinenko, V. I., and Kovalev, I. P. [A semisynthetic flavonoid from the Baikal skullcap (Scutellaria baicalensis) as an agent to enhance the efficacy of chemotherapy in experimental tumors]. View abstract. J Ethnopharmacol. View abstract. The antiinflammatory and analgesic effects of baicalin in carrageenan-evoked thermal hyperalgesia. Memorial Sloan Kettering does not assume any risk whatsoever for your use of this website or the information contained herein. 2008;6(1):103-8. Users of this Web site should not rely on information provided on this Web site for their own health problems. Select a condition to view a list of vitamins. Wu, J. Y., Chung, K. T., Liu, Y. W., Lu, F. J., Tsai, R. S., Chen, C. H., and Chen, C. H. Synthesis and biological evaluation of novel C(6) modified baicalein derivatives as antioxidative agents. Liu, J. J., Huang, T. S., Cheng, W. F., and Lu, F. J. Baicalein and baicalin are potent inhibitors of angiogenesis: Inhibition of endothelial cell proliferation, migration and differentiation. The root of Scutellaria baicalensis (SB) traditionally used for fever clearance and detoxification possesses various bioactivities including anticancer effects. Hui KM, Wang XH, Xue H. Interaction of flavones from the roots of Scutellaria baicalensis with the benzodiazepine site. This information may not fit your specific health circumstances. Apoptotic effects with the alkaloid scutebarbatine A occurs via cytochrome c and caspase-3/9 upregulation, and Bcl-2 downregulation(28). J Nat Prod 2009;72(9):1616-1619. Altavilla D, Squadrito F, Bitto A, et al. Zhou J, Qu F, Yu Y, et al. Song, S. H. and Wang, Z. Induction of apoptosis in prostate cancer cell lines by a flavonoid, baicalin. Scutellaria baicalensis Georgi extracts inhibit RANKL-induced osteoclast differentiation. Pharmacist's Letter/Prescriber's Letter. View abstract. Jeong, K., Shin, Y. C., Park, S., Park, J. S., Kim, N., Um, J. Y., Go, H., Sun, S., Lee, S., Park, W., Choi, Y., Song, Y., Kim, G., Jeon, C., Park, J., Lee, K., Bang, O., and Ko, S. G. Ethanol extract of Scutellaria baicalensis Georgi prevents oxidative damage and neuroinflammation and memorial impairments in artificial senescense mice. This Web site Information About Herbs, Botanicals and Other Products is for general health information only. Br J Pharmacol 2009;157:1410-18. Preclinical studies of S. barbata have focused mostly on colon, lung, and liver cancer models. View abstract. View abstract. The ethyl acetate (EtOAc) extract showed high ROS scavenging ability, and four compounds were subsequently isolated and purified from this extract: baicalin, baicalein, wogonin, and oroxylin A. Baicalein in rat lung mitochondria the most significant LHP-induced LPO inhibition was shown and extracted with EtOAc that contained the Your Query - This is a community service. Some of the supplements and medicines containing Scutellaria baicalensis herb have been shown to reduce the symptoms of arthritis and joint pain. Phytother Res 2000;14:210-2. J Ethnopharmacol. View abstract. Jiang, R. H., Su, W. C., Liu, H. F., Huang, H. S., and Chao, J. I. View abstract. Metformin (Glucophage) is used to help decrease blood sugar. View abstract. Biological properties of baicalein in cardiovascular system. New York, NY: CRC Press LLC. J Dermatol Sci 2007;46(1):31-40. View abstract. Kimura, Y., Matsushita, N., Yokoi-Hayashi, K., and Okuda, H. Effects of baicalein isolated from Scutellaria baicalensis Radix on adhesion molecule expression induced by thrombin and thrombin receptor agonist peptide in cultured human umbilical vein endothelial cells. View abstract. Further studies are needed. View abstract. Blood 2-15-2008;111(4):2354-2363. Some medications are changed and broken down by the liver. 6-29-2011; View abstract. Baikal skullcap might also cause sleepiness and drowsiness. Smol'ianinov ES, Gol'dberg VE, Matiash MG, et al. Treatments of Peyronie's disease with Scutellaria baicalensis and surgery according to the disease course: a single-center retrospective study of 261 patients. Moreover, many safety tests are not done; therefore, the medicines effectiveness and benefits are not completely known. View abstract. [Study on effect and mechanism of scutellaria baicalensis stem-leaf total flavonoid in regulating lipid metabolism]. View abstract. Some sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others. Taking large amounts of Baikal skullcap along with alcohol might cause too much sleepiness. Curr Drug Targets.Cardiovasc.Haematol.Disord 2005;5(2):177-184. The root has been used WebDescription:scutellaria baicalensis root extract is an extract of the roots of the scutellaria baicalensis, lamiaceae. Guang.Pu.Xue.Yu Guang.Pu.Fen.Xi. View abstract. View abstract. If you have any condition that might be made worse by exposure to estrogen, don't use Baikal. Zhongguo Zhong.Yao Za Zhi 2010;35(6):682-685. Induction of apoptosis in prostate cancer cell lines by a flavonoid, baicalin. Liu, W., Mu, R., Nie, F. F., Yang, Y., Wang, J., Dai, Q. S., Lu, N., Qi, Q., Rong, J. J., Hu, R., Wang, X. T., You, Q. D., and Guo, Q. L. MAC-related mitochondrial pathway in oroxylin-A-induced apoptosis in human hepatocellular carcinoma HepG2 cells. Before taking Baikal skullcap, talk to your healthcare provider if you take any medications that are changed by the liver. Toxicology 3-4-2009;257(1-2):80-85. Small studies in humans suggest that S. barbata may benefit patients with advanced breast cancer. View abstract. View abstract. View abstract. Yance, D. R., Jr. and Sagar, S. M. Targeting angiogenesis with integrative cancer therapies. 2nd ed. J Ethnopharmacol. Linnebur, S. A., Rapacchietta, O. C., and Vejar, M. Hepatotoxicity associated with chinese skullcap contained in Move Free Advanced dietary supplement: two case reports and review of the literature. 6-29-2011; View abstract. Li WJ, Bao J, Zheng DC, et al. 1987;33(2):80-84. Chen, S., Yuan, Y., Luo, Y., Huang, L., Chen, P., and Li, X. Keep in mind that natural products are not always necessarily safe and dosages can be important. Z., Wang, Y., and Liu, B. Baicalin induces human mucoepidermoid carcinoma Mc3 cells apoptosis in vitro and in vivo. Safety, tolerability, pharmacokinetics, and food effect of baicalein tablets in healthy Chinese subjects: A single-center, randomized, double-blind, placebo-controlled, single-dose phase I study. A., Han, D. Y., and Kim, G. S. Korean Scutellaria baicalensis water extract inhibits cell cycle G1/S transition by suppressing cyclin D1 expression and matrix-metalloproteinase-2 activity in human lung cancer cells. Huang, S. T., Wang, C. Y., Yang, R. C., Chu, C. J., Wu, H. T., and Pang, J. H. Wogonin, an active compound in Scutellaria baicalensis, induces apoptosis and reduces telomerase activity in the HL-60 leukemia cells. Baikal skullcap might have some of the same effects as estrogen. Zhongguo Zhong.Yao Za Zhi 2008;33(9):1064-1066. Immunopharmacology 2000;49:295-306. WebMD does not provide medical advice, diagnosis or treatment. S. barbata flavonoids have produced synergistic effects in combination with cisplatin in ovarian cancer cells(32). In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. Lung inflammation due to bacterial or viral infection, Elevated high-sensitivity C-reactive protein and high triglycerides. Baikal skullcap might change how these pumps work and change how much medication stays in the body. Baikal skullcap might lower blood pressure. 5-17-2011;135(2):359-368. Drugs 2005;65(9):1239-1282. Kim, B. R., Kim, D. H., Park, R., Kwon, K. B., Ryu, D. G., Kim, Y. C., Kim, N. Y., Jeong, S., Kang, B. K., and Kim, K. S. Effect of an extract of the root of Scutellaria baicalensis and its flavonoids on aflatoxin B1 oxidizing cytochrome P450 enzymes. Fu, J., Cao, H., Wang, N., Zheng, X., Lu, Y., Liu, X., Yang, D., Li, B., Zheng, J., and Zhou, H. An anti-sepsis monomer, 2',5,6',7-tetrahydroxyflavanonol (THF), identified from Scutellaria baicalensis Georgi neutralizes lipopolysaccharide in vitro and in vivo. Kong XT, Fang HT, Jiang GQ, et al. View abstract. WebThe root of Scutellaria baicalensis is used as medicine. Zhang, D. Y., Wu, J., Ye, F., Xue, L., Jiang, S., Yi, J., Zhang, W., Wei, H., Sung, M., Wang, W., and Li, X. Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis. Safety, tolerability, and pharmacokinetics of oral baicalein tablets in healthy Chinese subjects: A single-center, randomized, double-blind, placebo-controlled multiple-ascending-dose study. Eksp Klin Farmakol 1997;60:28-30. Baikal Scullcap, Baikal Skullcap Root, Chinese Skullcap, Escutelaria Asiatica, Huang Qin, Huangquin, Hwanggum, Ogon, Ou-gon, Racine de Scutellaire du Lac Bakal, Radix Scutellariae, Scullcap, Scute, Scutellaire, Scutellaire Chinoise, Scutellaire du Lac Bakal, Scutellaria, Scutellaria baicalensis, Scutellaria macrantha, Scutellariae Radix, Skullcap, Wogon. Different extracts of this herb have been found to kill cancer cells in the body, but human research is pending in this field. [The effect of an extract of Baikal skullcap (Scutelleria baicalensis) on succinic acid oxidation by the brain mitochondria in rats with hypoxia]. Talk with your healthcare provider before using this product if you are taking lithium. Statements made about products have not been evaluated by the Food and Drug Administration. Am J Chin Med 2001;29(1):69-81. Bonham, M., Posakony, J., Coleman, I., Montgomery, B., Simon, J., and Nelson, P. S. Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma. Razina, T. G., Udintsev, S. N., Tiutrin, I. I., Borovskaia, T. G., and Iaremenko, K. V. [The role of thrombocyte aggregation function in the mechanism of the antimetastatic action of an extract of Baikal skullcap]. Saifutdinov, R. R. and Khazanov, V. A. Sheng, J. P., Chen, H. R., and Shen, L. [Comparative study on selenium and amino acids content in leaves of planted and wild Scutellaria baicalensis]. Due to such properties, it is found that this medicine is prominent in dealing with cancer-producing cells. Users of this Web site should not rely on information provided on this Web site for their own health problems. Altern.Ther.Health Med. Bensky D, Gamble A, Kaptchuk T. Chinese Herbal Medicine Materia Medica. Bleeding disorders. Dry extract of Scutellaria baicalensis as a hemostimulant in antineoplastic chemotherapy in patients with lung cancer. View abstract. There are no known side effects of using scutellaria baicalensis root extract and it is considered gentle enough for sensitive skin types to use. Baikal skullcap might slow blood clotting. You, C. L., Su, P. Q., and Zhou, X. X. Letter/Prescriber's Letter. Eksp.Klin Farmakol. View abstract. Nutr Cancer 2004;49(2):217-22. 2000;4(3):289-291. Gasiorowski, K., Lamer-Zarawska, E., Leszek, J., Parvathaneni, K., Yendluri, B. Nutr Cancer 2007;57(1):100-110. Most studies have been done in the lab rather than in humans, and suggest anti-inflammatory and antioxidant activity. Chen C, Mireles RJ, Campbell SD, et al. This is especially relevant to macrophages and immune cells. Ciesielska, E., Wolszczak, M., Gulanowski, B., Szulawska, A., Kochman, A., and Metodiewa, D. In vitro antileukemic, antioxidant and prooxidant activities of Antoksyd S (C/E/XXI): a comparison with baicalin and baicalein. Reichenbach S, Juni P. Medical food and food supplements: not always as safe as generally assumed. 1998;61(5):27-29. B., Ro, J. Y., and Woo, S. S. Antiallergic herbal composition from Scutellaria baicalensis and Phyllostachys edulis. 1-8-2007;245(1-2):269-274. Bacteriostatic activity of combined application of Galla chinensis, Scutellaria baicalensis and Rhizoma coptidis against MRSA in vitro. J Ethnopharmacol. View abstract. View abstract. [Effects of light on flavonoids accumulation and related gene expression in suspension cultures of Scutellaria baicalensis]. Chan, F. L., Choi, H. L., Chen, Z. Y., Chan, P. S., and Huang, Y. Gao Z, Huang K, Yang X, Xu H. Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi. Induction of apoptosis by total flavonoids from. WebScutellaria Baicalensis Extract. Therapeutic Research Faculty 2020. Side effects are few and may include drowsiness. View abstract. Ye, F., Wu, J., Dunn, T., Yi, J., Tong, X., and Zhang, D. Inhibition of cyclooxygenase-2 activity in head and neck cancer cells by genistein. Preliminary study of traditional Chinese medicine treatment of minimal brain dysfunction: analysis of 100 cases. Pulm.Pharmacol Ther 2010;23(5):411-419. View abstract. 1995;15(8):465-467. Baikal skullcap might decrease blood sugar. PC-SPES (PDQ) - Health Professional Version. Eksp Klin Farmakol 1997;60:49-51. However, lab tests have shown that it is a herb that can reduce inflammation and have antioxidant properties. Guang.Pu.Xue.Yu Guang.Pu.Fen.Xi. Li L, Gao H, Lou K, et al. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. View abstract. Ai.Zheng. Zhang CZ, Wang SX, Zhang Y, et al. Yotsumoto, H., Yanagita, T., Yamamoto, K., Ogawa, Y., Cha, J. Y., and Mori, Y. Inhibitory effects of oren-gedoku-to and its components on cholesteryl ester synthesis in cultured human hepatocyte HepG2 cells: evidence from the cultured HepG2 cells and in vitro assay of ACAT. Huang, Y., Tsang, S. Y., Yao, X., and Chen, Z. Y. There is, for example, an algae extract trade-named Lanablue that comes from blue-green algae (green algae is rare, less than 1% of the total macroalgae in the world) and is claimed to have retinoid like effects (i.e. View abstract. Hou, Y. C., Lin, S. P., Tsai, S. Y., Ko, M. H., Chang, Y. C., and Chao, P. D. Flavonoid pharmacokinetics and tissue distribution after repeated dosing of the roots of Scutellaria baicalensis in rats. Integr.Cancer Ther. 2019;49(4):544-546. Phytomedicine. Memorial Sloan Kettering does not record specific website user information and does not contact users of this website. From: Polyphenols in Human Health and Disease, 2014. Call a physician if symptoms develop or persist. View abstract. View abstract. Kim, E. H., Shim, B., Kang, S., Jeong, G., Lee, J. S., Yu, Y. J Cell Biochem 12-15-2010;111(6):1629-1641. It is also used as a diuretic, and should not be confused with Scutellaria baicalensis. Phytomedicine. Zhang, S., Jin, Y., Zhu, W., Tang, J., Hu, S., Zhou, T., and Chen, X. Baicalin released from Scutellaria baicalensis induces autotoxicity and promotes soilborn pathogens. Intern Med 2001;40:764-8. Baikal skullcap might lower blood pressure. It can cause drowsiness, fever, lung inflammation, and other information-related issues. Baikal skullcap might cause sleepiness and slowed breathing. 36 Based on previous reports on pharmacological modulation of diabetes, hyperlipidemia and atherosclerosis View abstract. View abstract. Baikal skullcap might change how quickly the liver breaks down these medications. Lixuan, Z., Jingcheng, D., Wenqin, Y., Jianhua, H., Baojun, L., and Xiaotao, F. Baicalin attenuates inflammation by inhibiting NF-kappaB activation in cigarette smoke induced inflammatory models. Acute liver injury due to flavocoxid (Limbrel), a medical food for osteoarthritis: a case series. View abstract. Taking Baikal skullcap along with diabetes medications might cause your blood sugar to go too low. Small studies also suggest it is safe and may benefit patients with advanced breast cancer(13)(14). Liao, H. L. and Hu, M. K. Synthesis and anticancer activities of 5,6,7-trimethylbaicalein derivatives. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Baikal skullcap might have some of the same effects as estrogen. [Clinical and experimental study on inhibitory effect of sanhuang mixture on platelet aggregation]. 5. The safety of flavocoxid, a medical food, in the dietary management of knee osteoarthritis. 2nd ed. Copyright 2023 by RxList Inc. An Internet Brands company. 1998;61(1):37-39. WebScutellaria baicalensis extract containing baicalin (a flavone, type of flavonoid, is a major bioactive compound) has been used in traditional Chinese medicine to treat conditions of inflammation, hypertension, cardiovascular diseases, etc. Medications that cause sleepiness and drowsiness are called sedatives. Zhang, D. Y., Wu, J., Ye, F., Xue, L., Jiang, S., Yi, J., Zhang, W., Wei, H., Sung, M., Wang, W., and Li, X. Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis. - callus, root and suspension cultures of Baikal skullcap (Scutellaria baicalensis); For the obtained selected steadily growing callus cell cultures of medicinal plants of the Baikal skullcap (Scutellaria baicalensis), a preliminary analysis of the growth of the cultures was performed and the growth index was calculated. Case Reports Heptal 2016;2016:4356749. Bezielle selectively targets mitochondria of cancer cells to inhibit glycolysis and OXPHOS. Chemicals in skullcap might cause sleepiness. Three variants of meatballs were prepared: MBcontrol, without addition of S. baicalensis root extracts, MBWEwith the addition of water extract from S. baicalensis root, MBEEwith the addition of ethanolic extract from S. baicalensis root. Nontoxic; LD 50 is tested, none. View abstract. How It Works Purported Uses and Benefits Do Not Take If Side Effects Special Point Back to top For Healthcare Professionals Scientific Name Clinical Summary Purported Uses and Benefits Mechanism of Action Contraindications Adverse Reactions References Back to top # A B View abstract. Li BQ, Fu T, Gong WH, et al. View abstract. Yang, L., Zheng, X. L., Sun, H., Zhong, Y. J., Wang, Q., He, H. N., Shi, X. W., Zhou, B., Li, J. K., Lin, Y., Zhang, L., and Wang, X. Catalase suppression-mediated H(2)O(2) accumulation in cancer cells by wogonin effectively blocks tumor necrosis factor-induced NF-kappaB activation and sensitizes apoptosis. View abstract. Huang, Y., Tsang, S. Y., Yao, X., and Chen, Z. Y. Shang, Y. Pneumonitis induced by ou-gon (scullcap). Chen, L. G., Hung, L. Y., Tsai, K. W., Pan, Y. S., Tsai, Y. D., Li, Y. Some of these medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others. View abstract. Protective effect of baicalein extracted from Scutellaria baicalensis against lipopolysaccharide-induced glomerulonephritis in mice. Chen C, Mireles RJ, Campbell SD, et al. Song, S. J., Li, F. F., Xu, Y., Zhang, L. H., Yuan, F., and Zhang, Y. J Chem Ecol. Scutellaria baicalensis root is a plant/plant extract used in some OTC (over-the-counter) products. Bonham, M., Posakony, J., Coleman, I., Montgomery, B., Simon, J., and Nelson, P. S. Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma. Baikal skullcap might cause sleepiness and drowsiness. Wu, J., Hu, D., and Wang, K. X. However, low doses of baicalin upregulated expression of multiple angiogenic genes to increase cell proliferation in developing blood vessels, while high doses inhibited angiogenesis by inducing cell death, suggesting dose-dependent dual effects. Scutellaria baicalensis | Memorial Sloan Kettering Cancer Yune, T. Y., Lee, J. Y., Cui, C. M., Kim, H. C., and Oh, T. H. Neuroprotective effect of Scutellaria baicalensis on spinal cord injury in rats. View abstract. View abstract. https://herbpathy.com/Uses-and-Benefits-of-Scutellaria-Baicalensis-Cid5219, [Note: You are requested to write correct English only. Nutr Res 2009;29:298-304. View abstract. View abstract. Zhong.Yao Cai. Tsao, T. F., Newman, M. G., Kwok, Y. Y., and Horikoshi, A. K. Effect of Chinese and western antimicrobial agents on selected oral bacteria. View abstract. 1989;35(3):331-335. Typical doses (see individual product information): Dried herb: 1 to 2 g It is not an approved drug. 2009;30(11):1505-1512. FDA Alerts Consumers About Potentially Life-Threatening Health Problems Linked to Limbrel. The flavonoid baicalin exhibits anti-inflammatory activity by binding to chemokines. Consult your Doctor if you are Pregnant and Breastfeeding. Toxicol.Appl.Pharmacol 8-1-2011;254(3):221-228. 1-8-2007;245(1-2):269-274. J Ethnopharmacol. View abstract. Any questions regarding your own health should be addressed to your own physician or other healthcare provider. Huang KC. View abstract. Phytochemistry 2011;72(8):752-760. Vopr.Onkol. And Bcl-2 downregulation ( 28 ) enough for sensitive skin types to use how quickly the.... 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