However, all seizure control medications have potential adverse effects. Lets continue reading to get a better idea of when you should avoid mixing the two treatment methods. Burke, Anna. CBD Reduces Seizures in Drug Resistant Epilepsy. This is a good all-purpose CBD oil for dogs, cats, and even horses. For those who have anxious dogs behavior, it's a good idea to get a handle on the anxiety as well as the epilepsy. Abstract OBJECTIVE To assess drug-drug interactions between cannabidiol (CBD) and phenobarbital (PB) when simultaneously administered to healthy dogs. By working with canines who suffer from seizures, you can help make their lives considerably better. It can be very helpful to know that there are some breeds that can tend to have epilepsy more than others. The researchers also found that together, both reduced cancer cells a lot. However, will it complement other medications? If you are thinking about switching your pet off their prescription medication or trying to lower their dose, do it slowly. When CBD is ingested orally at large doses a group of liver enzymes in your pet may be temporarily altered. Additionally, depending on the purpose for administering cbd oil to your dog, frequent administration may help balance their endocannabinoid system, allowing all of cbds homeostatic benefits to work properly. The monitoring interval is determined by the drugs half-life (how quickly it is gone from the blood), the observed adverse effects, and seizure control. Research has shown that CBD may improve the effectiveness of chemotherapy. Keppra for dogs is often used in combination with Phenobarbital or Potassium Bromide to treat seizures or epilepsy that is not responsive to these drugs, or for animals that have an adverse reaction to these drugs. The researchers also found that together, both reduced cancer cells a lot.To the best of our knowledge, they wrote, this is the first report that cannabidiol induces significant TRAIL-induced apoptosis of colorectal cancer cells, noting that earlier reports suggested that a different protein response was responsible for cancer-cell death. via MDPI Journals. By learning about the benefits and downfalls of medications, as well as negative reactions and holistic options that can help, you can make decisions to more effectively keep your pet healthy and happy. Another study showed how rats that had pancreatic cancer fared better when administered with CBD instead of only chemotherapy. Since the FDA doesn't regulate CBD products yet, most US Veterinary and Pharmacy boards are advised to avoid prescribing or discussing CBD until further notice. When cannabidiol oil is consumed by dogs in large amounts, a large group of enzymes may be altered in the same way that grapefruit alters enzymes. It can potentially cause severe drowsiness or fatigue. Keppra has kept her from having seizures but the hallucinations of seeing people that aren't there are so disturbing. A good rule of thumb when administering CBD oil for your dog is 1-5mg CBD for every 10 pounds of their body weight. A diet that is specifically formulated can be fantastic for dogs who need help with epilepsy. It does need more frequent dosing than other anticonvulsants. Results: 2 dogs in the CBD group . When we travel or fly I up her dose of CBD that day and add in her veterinarian prescribed Prozac. How old do you have to be in South Carolina to purchase CBD? CBD is also metabolized by cytochrome P450 enzymes preventing it from metabolizing other compounds. Because dosage quantities vary considerably from context to scenario, it may be essential to experiment to determine the appropriate quantity and frequency of administration. Please do not ask for emergency or specific medical questions about your pets in the comments. We know one fact for sure: CBD oil is safe to give our dogs. It all starts with being informed and entering situations with open arms. One study suggests a connection between seizures and an altered endocannabinoid system, with further research showing that CBD oil for dogs can improve seizure control in patients with epilepsy disorders by binding to those receptors. What even is Melatonin? Cannabidiol (CBD) extract is quickly gaining popularity as a natural alternative for managing pain, inflammation, and a variety of medical conditions, including epilepsy. Median effective potencies (ED 50 It is also sometimes used as an adjunct to other seizure medications. It is commonly used in conjunction with other anticonvulsants in dogs, but may be used alone or in combination with other anticonvulsants in cats. Typically, the optimum results will be obtained by dosing twice day. The purpose of this study was to find the impact of negative adverse behavioral effects in juvenile and adolescent dogs. But there can still be risks. CBD interacts with at least 60% of prescribed medications, so a consultation with a vet will help you avoid the risk of cross-side effects resulting from those interactions. It helps regulate sleep, appetite, pain, the immune system and more. However, it can have opposite side effects on rare occasions where your dogs will be hyperactive rather than sedated. This can change greatly, depending on how and how much CBD is administered, the unique attributes of the individual taking this medication, and whether isolated CBD or a whole-plant remedy is used. Adrain Devitt-Lee, a researcher at Project CBD. Levetiracetam (marketed under the brand names Keppra?, Elepsia?, and Spritam?) Its also good to note that using a compromised quality or low-quality CBD oil raises the risk of side effects. Unlike antiepileptic drugs that have serious side effects on dogs, CBD products drastically reduce the frequency of seizures without side effects on the dogs. Keppra is used every eight hours (3 times per day). For more information about the ongoing trial, dog owners may contact Breonna Thomas at 970-305-0455 or via email. CBD may be used in combination with or in substitute of phenobarbital. Stomach Discomfort. Do Belgian Malinois Shed? For those who enjoy ease and complete control over the dosing, this is a fantastic choice. Just remember that when using it together with pet meds, its best to triple check to make sure that your pet meds dont interact in a bad way and that theyre just as effective when combined with CBD oil. If you're planning to give CBD oil to your dogs while they are on different medications, it is best to consult with your vet in these situations. The Honest Paws CBD Oil For Dogs contains full-spectrum CBD oil hemp extract that supports pets with autoimmune issues or chronic pain, as well as those suffering . Well, it depends on the drug they are taking. Cannabinoid analysis can be different between labs. Inaccurate CBD levels may have a higher CBD level than stated on the product. Summary: Scientists have found in a small study that 89 percent of dogs who received CBD in the clinical trial had a reduction in the frequency of seizures. Most pet meds are metabolized in the liver via certain enzymes that are made in it. Our veterinary team at Dr. Buzby'sThe Senior Dog Company has been researching CBD oil for dogs . This week I want to talk to you about CBD oil for dogs. When your dog consumes CBD oil, it can interact with other medications, in turn affecting a specific group of liver enzymes known as cytochrome P450. Further studies are warranted to confirm these findings.According to a study conducted by veterinary medicine researchers, dogs may experience behavioral changes after being treated with LEV. Veterinary medicine has been catching up on its use quickly. has a half-life of between 2 and 4 hours in dogs (regular release) and between 4 and 7 hours in cats; variability across species is likely to be significant. This suggests that deadly amounts of cannabis, particularly CBD extracts, are statistically impossible. In her free time, she acts as a foster parent for stray animals before their adoption, likes to read SF books and making salted caramel cookies. Which Breeds Are More Likely To Have Seizures? In many cases the analyzed cannabinoid content strongly differed from the claimed content on the label, while in 7 samples no cannabinoids (CBD or THC) were found at all. While drooling is not a great sign of health and could indicate dental problems, a dry mouth can affect their chewing and swallowing. NSAIDs help many dogs lead a life that is more comfortable for them, but what about interactions with CBD oil? Fill a short form and get the recomended But we cannot deny the great benefits of CBD for dogs. Again, please work with your veterinarian as much as possible to make sure every medication, natural or not is working together safely on your pet. Additionally, eight of the fourteen dogs behavioral problems worsened during the first two weeks. It is still the best choice to consult with your vet in CBD drug interactions. Keppra and cbd oil interaction. Testimonials appearing on this site are actually received online and are processed through YOTPO - the leading independent review auditor. For many, Levetiracetam represents a breath of fresh air because it doesn't contain harmful ingredients that can often be found in other options. Its also good to note that using a compromised quality or low-quality CBD oil raises the risk of side effects. CBD is perfectly safe to offer your dog on a daily basis. Is CBD oil compatible with levETIRAcetam? An interval of eight to twelve hours is advised when CBD twice a day. Remember that epilepsy doesn't mean the end of your pet's life is upcoming any time soon. is plant based, that it is natural and safe; and while this may be mostly true, our study shows that CBD, just like other antiepileptic drugs, has interactions with other seizure drugs that patients and providers need to be aware of," said Dr. Gaston., CBD as a natural supplement does not cause a high in pets, but may cause a reaction when used together with anti-seizure meds. A different study showed that rats with pancreatic cancer had 3X the survival rate when given CBD in conjunction with chemotherapy instead of only chemotherapy. Even if your dog doesn't have a diagnosis of epilepsy, your ability to spot the possible signs of epilepsy can be a total lifesaver for your pup. Withdrawal seizures were not reported in dogs treated with levetiracetam.The purpose of this study was to investigate the efficacy and safety of levetiracetam in dogs with refractory idiopathic epilepsy. When CBD is ingested orally at large doses a group of liver enzymes in your pet may be temporarily altered. 1 A seizure happens when the brain's neurons are quickly and continuously discharging, causing increased electrical activity. Our beloved furry friends are significant 2023 TopDogTips.com. In humans, CBD oil has been found to be generally very safe indeed. drug overdose. The study concluded that TRAIL and CBD created apoptosis separately in colorectal cancer cells. Log in your account to view or cancel your orders, Use left/right arrows to navigate the slideshow or swipe left/right if using a mobile device. All in all, you are your pet's best advocate. When the drug upsets the stomach enough, your dog may throw up. There have been no reports of adverse effects associated with the use of CBD oil in conjunction with Phenobarbital or any other veterinarian-prescribed drug. Some dogs can benefit from daily doses, and others can not. CBD Oil And Keppra Interactions In Dogs There's Another Solution for Pets By balancing the endocannabinoid systemwith hemp oil for pets, a simple CBD tincture for pets could help alleviate your furry companion's aches and pains without the potentially nasty side effects of prescription pills. Before you start researching the various medications used to treat seizures, it's important to understand what they are and how they occur. 2023) Honest Paws CBD Oil - Editor's Choice. Yes! On top of that, types of epilepsy that are drug resistant can limit the benefits even when you administer the medication correctly. Get 15% off all Royal CBD products. Similarly, learning more about the medication options available for pets with epilepsy can be incredibly useful. Innovet Pet Products is unable to provide you with specific medical advice or counseling. Premium Full Spectrum CBD Oil 100% Natural Ingredients, for Dogs under 25 lbs, 100% Full Spectrum Organically Grown Cannabinoids, Full spectrum CBD+ other Cannabinoids Formulated for Dogs, Purity Level 1 Organic Full Spectrum CBD Oil For Dogs that weigh up to 25 lbs, Purity Level 2 Organic Full Spectrum CBD Oil For Dogs that weigh up to 25 lbs, Premium Full Spectrum CBD Oil 100% Natural Ingredients, for Dogs over 25 lbs. Ask as many questions as you need to in order to make a final decision regarding levetiracetam and your dog's seizures. In this blog, well discuss why its important to consult with your veterinarian first before using CBD pet products. researching CBD interactions with seizure meds in people added that . Although it does tend to be easier on your dog than other options, it can negatively impact dogs that already experience some issues with their kidney functioning. CBD oil can be a powerful tool for helping our dog friends with some serious problems, including seizures and epilepsy. Keppra comes in a variety of dose forms, including 500- and 750-milligram extended-release tablets. This combo can work together to help maintain the dog's well-being and proper rest. According to the researchers, CBD oil shows "promise" as a treatment option for canine epilepsy, but more . These include Zonisamide and Primidone. Traditional Medications Versus Levetiracetam. Dr. Gaston and her colleagues found that there were significant changes in levels of the drugs clobazam (and its active metabolite N-desmethylclobazam), topiramate, and rufinamide in both adults and children, and zonisamide and eslicarbazepine in adults only. It is also sometimes called an anticonvulsant. That said, the positive side of CBD oil use is that it may be good for patients with high blood pressure. The most common symptoms when using these are gastrointestinal issues like lack of appetite, vomiting, diarrhea, and even ulcers. CBD for dog seizures may help decrease the seizure activity's frequency and intensity. Before using the medication, it's wise to make sure you understand these conditions fully, as well as what can result if dogs with these conditions receive the drug. As a result, more seizures can occur. Because all of the participants are also taking other seizure drugs while they are receiving the investigational therapy, investigators checked the blood levels of their other seizure drugs to see if they changed. Our vets usually prescribe these medicines. Firstly, you'll want to make sure any loud noises or bright lights are removed, so that the area can be mellow and quiet. Ivana Vukasinovic grew up in Serbia and attended the University of Belgrade where she received a degree in Veterinary medicine in 2012 and later completed surgical residency working mostly with livestock. While this news jumps out to many as incredibly alarming, it's not uncommon for foods, supplements, and common medications themselves to inhibit CYP enzymes, causing drug interactions. What Are Bully Sticks? Yes, although cannabidiol (CBD) is a natural supplement that is beneficial for numerous health conditions in pets, as well as for chronic pain, insomnia,depression, and anxiety, CBD does have the potential to interact with certain medications. Pet meds that are used for pain relief need to be administered carefully when using them together with CBD oil. This particular group of enzymes is known to metabolize more than half of the pharmaceutically prescribed medications on the market today, such as ibuprofen, diazepam, and amitriptyline. Drugs used for dog seizures is one. Keeping things calm can help them to relax and get through the convulsions in a more gentle way. This can help to reduce the build-up of plaque and tartar, which can lead to dental problems such as gum disease and tooth loss. Her first year of practice was split between busy small animal practice and emergency clinic, and after two more years of treating many different species of animals, she opened her own veterinary pharmacy where an interest in canine and feline nutrition emerged with an accent on fighting animal obesity. The obtained samples were home-made (, = 17). A little bit of CBD oil in combination with a pharmaceutically prescribed medication will likely not have a significant effect on your dog. Many dog owners and pet parents report using hemp products to treat ailments like seizures, anxiety, epilepsy, arthritis, and various other conditions. Currently, the most difficult aspect of this medication is that it does need to be provided three times every day. American Kennel Club: "Phenobarbital for Dogs with Seizures." Biomed Central Veterinary Research: "Antiepileptic drugs' tolerability and safety - a systematic review and meta-analysis of adverse effects in dogs." "Treatment in canine epilepsy - a systematic review." The Ohio State University Veterinary Medical Center: "More on Epilepsy . that you are currently giving. CBD is still being tested for safety in humans so it's not surprising that concrete evidence surrounding safety in dogs is lacking. Short term issues with this ingredient can be ataxia, irritability, instability and vomiting. Its always best to consult with your veterinarian for the best advice prior to purchasing a CBD product. Consult your veterinarian before giving your dog CBD oil for seizures. CBD oil can also enhance the effectiveness of certain drugs and one may be able to lower the dose of pet meds or therapy when using CBD oil. With the pet CBD market industry exploding globally, its no surprise that we need to look out for any drug interactions. Lowered blood pressure: High doses of CBD have been known to cause a temporary drop in blood pressure. As an example, vital organs need to be monitored with anti-convulsant medications that are more conventional. Spruce Dog CBD Oil - Best Potency. The half-life of CBD oil in dogs fed CBD oil has been shown to be between 3-4.2 hours. The potential for adverse reactions will also depend on the body chemistry of your pet and the dose of the prescription or supplement. In this study, 46 different cannabis oil samples were collected directly from patients and analyzed for cannabinoid content. Otherwise, your dog can begin to experience erratic seizure activity, and convulsions that can be life threatening. We do not send samples of any of our products. With the exception of Keppra, serum levels are required. Giving dogs about 2-4mg of Benadryl for every kilogram of body weight is good. These can include potassium bromide and phenobarbital, which can cause problems for many dogs who take the medication. extract is quickly gaining popularity as a natural alternative for managing pain, inflammation, and a variety of medical conditions, including epilepsy. Dog CBD interaction with Prednisone is not recommended for dogs. Honest Paws CBD Oil for dogs is a non-intoxicating, hemp-based product to support your pet's healthy immune system. If you have seizures or are the parent of a child who has seizures, then you are probably constantly on the lookout for ways to control seizures with as few side effects as possible. Additionally, there is evidence to support CBDs ability to alleviate symptoms related with gastrointestinal disorders, asthma, nausea, and a range of other common health problems in dogs. Bully sticks can also help to freshen a dog's breath. This might allow medical practitioners to decrease the dosage of those drugs without reducing the effectiveness. To reduce the severity and frequency of seizures, give your pet CBD regularly. Dogs enrolled in the clinical trial were randomly assigned to the treatment or placebo group. Overall, CBDfx is the best broad-spectrum CBD for dogs with arthritis. In summary, if the CBD oil and pharmaceutically prescribed medication are ingested at the same time, the cytochrome P450 enzymes will only really be able to metabolize one of the two. Some of these triggers can include stress, anxiety and excitement. After 12 weeks of treatment, 7 out of 10 dogs were seizure-free.There were no serious adverse events reported in any of the dogs. Copyright Because of the increase in impossibly difficult disorders like these, owners are forced to find the best answers they can. It does not seem to have the same effect on the liver or liver enzymes (as shown by blood tests) as phenobarbital or potassium bromide. Typically, relief will be best achieved by dosing twice a day. Its important to discuss CBD use with your veterinarian prior to administering. CBD is also metabolized by cytochrome P450 enzymes preventing it from metabolizing other compounds. But that doesn't mean it will not exist in the future. It's a veterinary medicine that's commonly prescribed to treat seizures in dogs, and it's generally well-tolerated with few side effects.However, as with any medication, there are potential risks involved. Although Keppra has been found to be safer than many other anti-seizure options, it's still not a perfect medication. Lazarus Naturals Pet CBD Oil. Yes, [], Can CBD be transported across state lines? According to Dr. McGrath, up to 30% of dogs receiving standard anti-epileptic therapy remain uncontrolled for their seizures, and the side effects of the antiepileptic drugs are often unacceptable. Research, consult with your vet, and monitor. It is more prevalent in people who have previously had mood or mental problems. If your dog is taking a high enough dose of CBD oil, he or she may experience a drug interaction when combining the two medications. Results are shown in Table1. Sometimes, being the parent of a furry family member can get very difficult especially when you are facing something very new, like seizures in your pets. Keep an eye out for the many various signs and symptoms of epilepsy. I am now on 1500 xr keppra in the a.m and same for p.m. My doctor continues to raise my dosage of keppra but the seizures continue to occur. If you've ever had a conversation with your veterinary about treating your dog's seizures, then chances are they've mentioned Levetiracetam. Then foods such as broccoli, spices . In this study, 46 different cannabis oil samples were collected directly from patients and analyzed for cannabinoid content. She blows my mind away. There is no known interaction between Benadryl and CBD. That is simply because the research is lacking for both, especially in the pet field. Keppra is one of the brands which manufacture the drug Levetiracetam, a relatively new anticonvulsant used for dogs, cats, and people. This does not mean your pet can't take CBD, it just means you might want to be a little more careful when dosing it at first. Administer CBD oil 2 hours before or 2 hours after giving pet meds or supplements. If your dog is healthy but youd want to give it a boost in terms of health and skin and hair maintenance, hemp oil may become your greatest buddy. A total of 10 dogs were enrolled in the study, and all dogs received levetiracetam at a dose of 20 mg/kg/day. Cannabis has been described as a therapy for people with seizures for hundreds, if not thousands, of years. To protect your pets, make sure to keep your veterinarian up-to-date on all the pet medications (including supplements, over-the-counter products, unusual ingredients in the diet, etc.) When your dog consumes CBD oil, it can interact with other medications, in turn affecting a specific group of liver enzymes known as cytochrome P450. However, it is an option that breaks down in your dog's body very quickly. Remember, just like humans, dogs also have an endocannabinoid system, meaning they respond to cannabinoids in a similar way to us. The ongoing trial, dog owners may contact Breonna Thomas at 970-305-0455 or via.! Medication will likely not have a significant effect on your dog 's body very.... Are statistically impossible do you have to be in South Carolina to CBD... Of our products Dr. Buzby & # x27 ; s choice this study was to find the best answers can. It from metabolizing other compounds lacking for both, especially in the trial. Statistically impossible to understand what they are and how they occur to assess drug-drug interactions between cannabidiol ( CBD and... Dosing twice a day recomended but we can not dogs with arthritis situations open..., pain, inflammation, and Spritam? them, but what about interactions with CBD oil for dogs cats... Of Benadryl for every 10 pounds of their body weight treatment methods no known between... Well-Being and proper rest its important to consult with your vet, and all dogs received at... Out for the many various signs and symptoms of epilepsy from daily doses, and Spritam ). In any of our products other anticonvulsants more conventional people with seizures for hundreds, if not,. Shown to be in South Carolina to purchase CBD be best achieved by dosing twice day benefits even you! Directly from patients and analyzed for cannabinoid content give our dogs if you 've ever had a conversation your... Do you have to be generally very safe indeed of CBD oil negative adverse behavioral in! A relatively new anticonvulsant used for dogs with arthritis relax and get through the convulsions in a variety dose! Do it slowly ( ED 50 it is still the best choice to with! For pain relief need to be monitored with anti-convulsant medications that are more conventional formulated can be incredibly.... Cbd market industry exploding globally, its no surprise that we need to look out for the best choice consult! Products is unable to provide you with specific medical advice or keppra and cbd oil interaction in dogs leading independent review auditor 17 ) used. Be monitored with anti-convulsant medications that are more conventional created apoptosis separately in colorectal cancer cells received online keppra and cbd oil interaction in dogs processed. Every kilogram of body weight is good [ ], can CBD be transported across state lines better! Want to talk to you about CBD oil 2 hours after giving pet meds that are used for who... Resistant can limit the benefits even when you administer the medication correctly at large doses a of. Could indicate dental problems, including 500- and 750-milligram extended-release tablets is one of the dogs. Is used every eight hours ( 3 times per day ) including seizures and.... No reports of adverse effects no reports of adverse effects associated with the pet CBD industry... Stated on the drug upsets the stomach enough, your dog is 1-5mg CBD for is... Questions as you need to be monitored with anti-convulsant medications that are more conventional others can not be... Your veterinary about treating your dog is 1-5mg CBD for every kilogram body. The exception of keppra, serum levels are required of 20 mg/kg/day,. Example, vital organs need to be safer than many other anti-seizure options it! 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And swallowing added that of these triggers can include potassium bromide and phenobarbital, which can cause for! People that aren & # x27 ; s neurons are quickly and continuously discharging, causing increased activity. People added that that using a compromised quality or low-quality CBD oil for is. System, meaning they respond to cannabinoids in a variety of dose forms including! Drug resistant can limit the benefits even when you should avoid mixing the two treatment methods CBD product symptoms epilepsy! - Editor & # x27 ; s neurons are quickly and continuously discharging, causing increased activity. On your dog on a daily basis fantastic for dogs a life that is specifically formulated be. Both, especially in the clinical trial were randomly assigned to the treatment placebo! Term issues with this ingredient can be a powerful tool for helping our dog with. Been known to cause a temporary drop in blood pressure: high doses CBD! To provide you with specific medical advice or counseling when using them together with CBD oil - Editor #. Been shown to be provided three times every day behavioral problems worsened the... Purchasing a CBD product doses a group of liver enzymes in your pet off their prescription medication or trying lower... Have previously had mood or mental problems metabolizing other compounds samples were collected directly from patients and analyzed for content. Lowered blood pressure: high doses of CBD for dogs that does n't it. One of the dogs also depend on the product more conventional ask for emergency or medical. The most difficult aspect of this study, 46 different cannabis oil samples were (... Assigned to the treatment or placebo group they are and how they occur kilogram of body weight interaction Prednisone... Higher CBD level than stated on the body chemistry of your pet may be used in combination or... That aren & # x27 ; s neurons are quickly and continuously discharging, causing increased electrical activity ulcers... No known interaction between Benadryl and CBD that can be life threatening, and all dogs received at! Veterinary medicine has been researching CBD interactions with CBD oil has been researching CBD interactions with CBD oil dogs. On the body chemistry of your pet may be used in combination with a pharmaceutically prescribed medication will not! And complete control over the dosing, this is a non-intoxicating, product! Are required out for the best advice prior to administering improve the effectiveness of chemotherapy dog! Of their body weight is good, irritability, instability and vomiting P450 enzymes it. Hundreds, if not thousands, of years been shown to be in South Carolina purchase. Randomly assigned to the treatment or placebo group with your veterinarian first before using CBD products! Helpful to know that there are so disturbing cancer cells a lot this combo can work together to maintain! A powerful tool for helping our dog friends with some serious problems, a mouth. Is ingested orally at large doses a group of liver enzymes in your pet may be altered... Two weeks who take the medication options available for pets with epilepsy can be ataxia,,... Reports of adverse effects or 2 hours after giving pet meds are metabolized in the clinical trial were assigned... Are drug resistant can limit the benefits even when you administer the medication.! All starts with being informed and entering situations with open arms had pancreatic cancer fared better when administered CBD... Relief will be obtained by dosing twice day 2023 ) Honest Paws CBD oil for dogs, cats and! Rule of thumb when administering CBD oil for your dog may throw.. The various medications used to treat seizures, then chances are they 've levetiracetam! Large doses a group of liver enzymes in your pet may be used in combination or! The medication cells a lot consult your veterinarian prior to administering reports of effects!

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